In 1959, she moved to the United States, and showed her Italian works in New York and Washington, DC, again to critical and popular acclaim.
From 1960 to 1981, she worked for the Washington Star newspaper as a contributing artist, giving readers artistic interpretations of events such as the 1968 Democratic National Convention and White House Easter Egg Rolls.
Lily Spandorf said of her Advise and Consent drawings, "I combined the action on both sides of the camera with the setting of the U.S. Capitol and Washington. The images capture the events surrounding this unique filming–the only time the interior of the Capitol has been used as a movie set."
Many of Spandorf's other works are showcased in Lily Spandorf's Washington Never More by Mark G. Griffin and Ellen M. McCloskey, which is a collection of sketches depicting Washington, DC neighborhoods and buildings. This work is particularly significant because many of the buildings illustrated in the book are no longer standing today.
Her work will be displayed at the George Washington University Museum (Nov 21 2015 – Dec 31 2016), along with her celebrated depictions of 19th-century buildings in urban DC as they faced demolition.